The selected genes (TIMP-2, AKR1B1, MMP-2, MMP-9, MYL9, SCL2A4, SCL2A1, SCL4A3) are associated with different cellular pathways for the progression of T2D to T2D with microalbuminuria and macroalbuminuria. The gene discussed is AKR1B1; the disease is type 2 diabetes mellitus.