TLR4 and cervical squamous intraepithelial neoplasia: In summary, atorvastatin protected tubular epithelial cells from injury probably by suppressing TLR4 expression, regulating the TLR4/Myd88 signaling pathway, and inhibiting the expression of downstream inflammatory cytokines, such as IL-1β, IL-6, and MCP-1, indicating that TLR4/Myd88/NF-κB are indeed involved in the occurrence and development of CIN.