In addition to its suppression by mTORC2, the expression of FoxO3a is suppressed by miR-mediated mechanisms in GBM. FoxO3a is negatively regulated by miR-27a, which is highly expressed in GBM relative to low WHO grade glioma and normal brain and is associated with faster disease progression and shorter patient survival [84]. Here, FOXO3 is linked to central nervous system cancer.