In colon cancer, these three miRNAs, miR-340, miR-124, and miR-137, which target hnRNPI/hnRNAPA1/hnRNAPA2, are downregulated in order to promote the mutually exclusive alternative splicing of PK into the PKM2, which is a key metabolic adaptation in cancer [159]. This evidence concerns the gene PTBP1 and malignant colon neoplasm.