PKM and tongue squamous cell carcinoma: In tongue squamous cell carcinoma (TSCC), the glycolytic enzyme, PKM2, is targeted by miR-133a/133b, which are downregulated in TSCC and in GBM [164–166] Moreover, miR-122, which also targets PKM2, is downregulated in hepatocellular carcinoma (HCC) [167] and GBM, where it correlates with shorter patients survival [168].