Firstly, miRNAs can directly regulate the expression of genes taking part in glucose uptake and glucose metabolism in GBM, miR-106a regulates GLUT3 [66], miR-143 regulate HKII [67], and let-7-a and miR-326 regulate PKM2 [34, 68], which will be detailed in Section 5. The gene discussed is HK2; the disease is glioblastoma.