Our study aims to characterize the expression of chemokines and chemokine receptors involved in the migration of mesenchymal stem cells such as the SDF1/CXCR4 and CCR7/CCL19 CCL21 axes, in BM-MSCs of COPD patients in comparison to healthy subjects with similar age and smoking histories. The gene discussed is CXCR4; the disease is chronic obstructive pulmonary disease.