JAK2 and myeloid sarcoma: For example, in an analysis of 61 SNPs in 34 candidate genes as possible determinants of IFNβ response in Irish patients with MS, the most significant allelic combinations that differed in frequency between responders and nonresponders included JAK2–IL10RB–GBP1–PIAS1, followed by JAK2–IL10–CASP3 [59].