TNFSF10 and cancer: Compressive forces can act to flatten the glycocalyx protection layer around cancer cells, thus allowing TRAIL to come into closer contact to the cancer cell death receptors for apoptotic action.98 This approach is intended to neutralize rare CTCs in blood, and the margination of leukocytes and CTCs along the vessel wall results in CTCs becoming surrounded by the circulating leukocytes (Fig. 3g).