In another project, we evaluated the efficacy of the same TRAIL/ES liposomes to prevent the spontaneous formation and growth of metastatic tumors in an orthotopic xenograft model of prostate cancer.145 Prostate cancer is known for having poor prognosis and limited treatment options once it has progressed from its local to metastatic form. This evidence concerns the gene TNFSF10 and Familial prostate cancer.