TNFSF10 and malignant colon neoplasm: In 2012 our group demonstrated, for the first time, that fluid shear stress could sensitize certain human cancer cells to TRAIL-induced apoptosis.97 In that study, human colon cancer COLO 205 and prostate cancer PC-3 cells were treated with TRAIL and then exposed to fluid shear stress in a cone and-plate viscometer.