SOD1 and amyotrophic lateral sclerosis: Mice accumulate mutant SOD1 aggregates in the spinal cord, leading to motor neuron death and recapitulation of the central aspects of ALS pathology including an age-dependent accumulation of CD11b+ (Alexianu et al., 2001; Gowing et al., 2008), CD68+ (Henkel et al., 2006; Beers et al., 2011), MHC II+ (Hall et al., 1998), CD11c+ (Beers et al., 2011) microglia/macrophages in the spinal cord of mSOD1 mice.