This may therefore be consistent with D2R/D3R agonist bromocriptine's efficacy in the treatment of T2D based on findings that it reduces plasma glucose, triglyceride, and free fatty acid levels, and significantly decreases hemoglobin A1C levels as compared to placebo (Holt et al., 2010; Valiquette, 2011). This evidence concerns the gene DRD2 and type 2 diabetes mellitus.