PRDM16 and hereditary elliptocytosis: In the present study, GTE significantly induced PPAR-γ, PRDM-16, PGC-1α, BMP-7, and FGF-21, and reduced TLE-3, which was associated with enhancement of the browning biomarkers, UCP-1, CIDEA, and CPT-1, in the 1X and 2X groups compared to the HE group.