L-HDL-ApoA2, M-HDL-ApoA2, XS-LDL-ApoB and XXL-LDL-triglycerides are associated with increased risk of type 2 diabetes, whereas L-HDL-free cholesterol, XXL-LDL-phospholipids and L-LDL-cholesterol are associated with decreased risk of type 2 diabetes. This evidence concerns the gene APOB and type 2 diabetes mellitus.