Key features of TAMs such as the production of tumor-promoting factors (e.g., PGE2, VEGF, EGF (epidermal growth factor), TGF-β (transforming growth factor-β), or MMP9 (matrix metalloprotease)), poor ROI production, high anti-inflammatory cytokine, and low proinflammatory cytokine production emerge as a consequence of macrophage interaction with apoptotic cells [72]. Here, MMP9 is linked to neoplasm.