The emerging role of apoptotic cell-derived S1P in triggering macrophage effector functions, especially the axis of NLRP3 inflammasome activation, IL-1β release, and lymphangiogenesis, as well as the S1P-LCN2 connection in the tumor microenvironment may pave a way for a new drug target discovery in cancer and inflammation. This evidence concerns the gene NLRP3 and neoplasm.