In Kasumi-1 cells, binase switched on a number of regulatory mechanisms including noncanonical NF-κB signaling pathway [17]; in T-cell acute lymphoblastic leukemia Jurkat, binase induced apoptosis and reduced transcription factor NF-κB level [28]; therefore, NF-κB signaling apparently is a common feature of the action of RNases on cancer cells. The gene discussed is NFKB1; the disease is cancer.