Beatty et al. could demonstrate within the “Heart And Soul” cohort that a risk model containing hsTnT and NT-proBNP, combined with urine albumin-to-creatinine ratio (uACR) and current smoking, was able to better discriminate patients with stable CAD and an increased risk for a first acute myocardial infarction [36]. The gene discussed is NPPB; the disease is myocardial infarction.