CUL3 and head and neck squamous cell carcinoma: Associations of some SNPs in WNK1 and WNK4 with EH have been observed in the general population [12–14], and one study had identified that rs3738952 of CUL3 was significantly associated with head and neck squamous cell carcinoma (HNSCC) risk [15], but very few reports investigated the relationship between SNPs of CUL3 and EH [16].