LMNB1 and progeroid syndrome: In agreement with this, large-scale chromatin relaxation and aberrant transcription were specifically linked to Lamin B1 depletion in senescent fibroblasts and progeria cells.15, 16 Furthermore, age-associated loss of Lamin B1 has been reported to lead to systemic inflammation in Drosophila due to the derepression of a large number of immune responsive genes.17 These data strongly suggest the restrictive role of LADs in epigenetic gene regulation.