SNCA and Parkinson disease: When applied to CSF samples from 46 patients with Parkinson’s and 48 healthy age-matched controls, the ELISA targeting aggregated a-syn demonstrated the highest sensitivity for detecting PD patients compared with those detecting total or phosphorylated alpha-synuclein (89 vs 74% and 54%, respectively), but the lowest specificity (52 vs 74% and 54%, respectively).