While Ryan et al. showed that 17 genes in cancer-related signal transduction pathway are downregulated in EBV-infected AGS cells28, eight of them, BATF, COX2, TFF1, ID2, CDK2, CCND1, CDKN2A, and ID4, were also downregulated in EBV-infected MKN7 cells. The gene discussed is CDKN2A; the disease is cancer.