For example, 4 miRNAs (hsa-miR-222-3p, hsa-miR-146a-5p, hsa-mir-221-3p and hsa-miR-126-5p) from the top 10 immature T-ALL specific miRNAs (Fig. 2c) also showed significant higher expression in CD34+ vs. CD4+CD8+ T-cell subsets (Fig. 4a). This evidence concerns the gene CD8A and acute lymphoblastic leukemia.