TLR2 and Granuloma: The fine tuning of the inflammatory response, in particular through TLR2 signaling, is thought to be a strategy developed by the tuberculosis bacillus to achieve the various steps of its infectious cycle, from survival of the initial encounter with the host, to persistence in granulomas and finally to the induction of the central necrosis and rupture of the granuloma favoring bacterial release in the airways and transmission33.