Our results showed that treatment with Minnelide resulted in accumulation of HIF-1α within the pancreatic tumor (in both patient derived xenografts as well as in a spontaneous mouse model KRASG12DTP53R172HPDXCre or KPC for pancreatic cancer) even though the hypoxia and hypoxia mediated signaling was decreased. Here, HIF1A is linked to familial pancreatic carcinoma.