However, such explanation is not easily reconciled with the fact that Ly promoted no more hyperkalemia than Eple (in fact, hyperkalemia was less frequent in Ly- than in Eple-treated rats, although the difference between the two groups did not achieve statistical significance), an unexpected finding given that major downstream mediators, such as SGK1, drive both proinflammatory and mineralocorticoid effects of Aldo. This evidence concerns the gene SGK1 and Hyperkalemia.