Following adjustment for age, sex, baseline eGFR, SBP, PVD, diabetes, primary renal disease, and ACEi/ARB or aspirin use, our model, using the high sCD40L/low sCD40R as the comparator group, identified low sCD40L/high sCD40R as a statistically significant independent predictor of attenuation of renal function decline (3.21 ml/min per 1.73 m2 per year; p = 0.016). This evidence concerns the gene CD40LG and diabetes mellitus.