As we found that cisplatin-resistant cells were more resistant to cytotoxic action of NK cells, we then investigated whether the higher resistance of cisplatin-resistant lung cancer cells to NK cell cytotoxicity than parental cells was due to the alteration of PD-L1/NKG2D ligand levels in cisplatin-resistant lung cancer cells and PD-1/NKG2D levels in NK cells. This evidence concerns the gene CD274 and lung cancer.