AKT1 and Mental deterioration: Here, we found that luteolin is a potent inhibitor similar as rapamycin to block mTOR/4E-BP1 as well as the expression of AKT and p70S6K and down-regulate the expression of pro-apoptotic protein Bax, Cyt C and casepase-3, indicating that it could be developed into an effective treatment for cognitive decline (Fig. 5).