Using PC12 cell cultures, which are an established model for the investigation of nervous system disease39–41, we examined the role of pro-apoptotic proteins (Bax, Cyt C and caspase-3) and their related signaling molecules mTOR/4E-BP1 in the prevention of MG-induced neuronal apoptosis, which mimics the diabetics state. Here, MTOR is linked to diabetes mellitus.