GDF15 and Parkinsonism: More recently Macahado et al., have described the importance of Gdf15 in the survival of dopaminergic neurons through a similar model of Parkinsonism as in Strelau et al., showing that Gdf15 knockout mice are more severely affected than the wild-types with a greater loss of dopaminergic neurons in response to 6-OHD intoxication55.