Emerging evidence has indicated that increased activity of N-glycosylation is implicated in several pancreatic cancer pathways, including TGF-β, TNF, and NF-kappa-B12, and inhibition of N-glycosylation can markedly reduce chemoresistance of pancreatic cancer cells13, 14. The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.