Regular aerobic exercise reduces breathlessness and muscle dysfunction for individuals with CHF while improving exercise capacity.4–6 According to the ExTraMATCH meta-analysis,7 exercise training leads to a 35% relative reduction in mortality, similar to the effects of beta-blockers8 and angiotensin-converting-enzyme inhibitors.9 However, those with advanced CHF are often so limited that they are unable to gain the holistic benefits of exercise.4 7. The gene discussed is ACE; the disease is congestive heart failure.