CLDN3 and ovarian carcinoma: For example, CLDN3 (Claudin-3; ProGENI rank 4), a gene that is involved in tight junction-specific obliteration of the intercellular space, has been shown to regulate sensitivity to cisplatin by controlling expression of cisplatin influx transporter CTR1; in addition, knockdown of CLDN3 has been shown to increase resistance to cisplatin in human ovarian carcinoma cells in both in vitro culture and an in vivo xenograft model [29].