Type II diabetes (T2D) impairs anabolic signaling in skeletal muscle as shown by Stephens et al. [1] who reported a decrease in eukaryotic initiation factor 4E binding protein 1 (4EBP1) phosphorylation which, in turn, was associated with decrements in overall muscle protein synthesis. Here, EIF4EBP1 is linked to type 2 diabetes mellitus.