Zhu et al. recently reported that RXRα agonist bexarotene treatment attenuated myocardial hypertrophy in spontaneously hypertensive rats by modulating the activation of the liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK)/p7056 kinase signaling pathway, which occurs independently of the BP [40]. The gene discussed is RXRA; the disease is cardiac hypertrophy.