We have previously shown that the PPARγ agonist pioglitazone inhibited both Ang II- and potassium-mediated aldosterone synthase gene (CYP11B2) transcriptional activation via Ca2+/calmodulin-dependent kinase (Ca2+-CaM-CaMK) inhibition in H295R cells derived from human adrenocortical carcinoma [14]. The gene discussed is CYP11B2; the disease is adrenal cortex carcinoma.