Taken together, although rs2075650, in the TOMM40 region, associates with rDR level in our study, and with episodic memory (p<5.0x10-08) and late-onset Alzheimer disease (LOAD) in other studies, that effect on verbal information retrieval detected through GWAS is primarily driven by linked APOE variants [6]. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.