The network (S7 Fig), shows that TOMM40 has possible interactions or functions in conjunction with several genes (i.e., APOE, BAX, INSR, APP, VDAC4, FOXB1, SNCA, HSD17B10, HSPA4) in the pathway of influence on verbal memory, episodic memory, AD, cognitive impairment, memory deficits, and reduced hippocampal volume. The gene discussed is APP; the disease is Alzheimer disease.