IPA analyses was seeded with established risk genes for AD (listed via AlzGene: APOE, BIN1, CLU, ABCA7, CR1, PICALM, MS4A6A, CD33, MS4A4E, CD2AP) and from the current study, as associated with rDR-L and IR-C, in order to elucidate relationships between genes and the variants involved in AD-related processes. The gene discussed is BIN1; the disease is Alzheimer disease.