Since CX3CL1 is expressed by CD68 and CD11b monocytes/macrophages and cardiac fibroblasts (S1 Fig), the upregulation in LV CX3CL1 expression in CVB3-infected mice can partly be explained by the increase in monocytes/macrophages (Fig 2) and cardiac fibroblast presence (Fig 5) in myocarditis mice. The gene discussed is CD68; the disease is myocarditis.