SSTR1 and neoplasm: The highest sensitivity of BON-1, followed by H727 cells, might be due to stronger BYL719-induced apoptosis as a potential consequence of GSK3 inhibition and tumor cell re-differentiation with significant SSTR1/2 up-regulation, in contrast to lower apoptosis induction, absent GSK3 inhibition and absent re-differentiation in QGP-1 cells [71, 72, 85, 101, 106, 107].