The low baseline phosphorylation/activity of the IGF1R in BON1 and H727 cells might not have been sufficient to show the effects of specific IGF1R inhibition by NVP-AEW541; moreover, others have shown a dependence of GSK3 phosphorylation on IGF1R activity in medulloblastoma cells [49], but they stimulated their cells with IGF1 to demonstrate clear results. The gene discussed is IGF1; the disease is medulloblastoma.