PRRT2 and neuroendocrine neoplasm: To evaluate the influence of BYL719-induced cell differentiation and signaling on CgA secretion in neuroendocrine tumor cells, BON-1, H727 and QGP-1 cells were analyzed for their release of CgA when treated with either vehicle, the known PKC activator and secretagogue phorbol-12,13-dibutyrate (PDBu), or two concentrations of BYL719.