MYC and Burkitt lymphoma: Consequently, anti-apoptotic mutations synergise with myc to promote malignant transformation4, 13, 15, 40, 44, 51 and the pre-B and B lymphomas that eventually arise in Eμ-myc mice often harbour mutations that mutate p53 or its upstream regulators,15 as do Burkitt lymphomas.18, 19, 31, 54