AKT1 and colonic neoplasm: Furthermore, proteoglycanpurified from P. linteus suppressed colon cancer by protecting T cells and disrupting the EGFR/AKT pathway [13,14], and inhibited SW480 colon cancer cell growth by G2/M phase arrest and suppressed tumor growth in a xenografted model by altering the Wnt/β-catenin pathway [15,16].