It has been known that pAKT T308 was upregulated by TAC via the activated PI3/PDK1 signaling, resulting in the activation of mTORC1 substrates, which leads to cardiac hypertrophy; however, the change and the role of pAKT S473 in the TAC‐induced hypertrophy remain controversial. The gene discussed is PI3; the disease is cardiac hypertrophy.