In a study based in the USA, Landon et al. demonstrated that pregnancies in women diagnosed with GDM using the CC criteria and randomized to treatment with education, diet, and, if necessary to achieve goals, insulin resulted in lower rates of macrosomia (5.9 vs 14.3%, p < 0.001) and preeclampsia (8.6 vs 13.6%, p = 0.01) [14]. This evidence concerns the gene INS and preeclampsia.