In the present study it was found that both groups of preeclamptic patients with early- and late-onset preeclampsia had significantly higher MMP-2 levels than the healthy controls and were distributed as follows: 242.93  ±  68.64 ng/mL (136.88–466.90 ng/mL) in earlyPre, 234.39.7 ± 79.18 ng/mL (124.19–514.79 ng/mL) in late-onset preeclampsia, and 195.30 ± 43.53 ng/mL (103.88–347.83 ng/mL) in the control group. This evidence concerns the gene MMP2 and preeclampsia.