In addition, MIF has a critical role during infection by many parasites, including Leishmania major (Satoskar et al., 2001) and T. cruzi (Reyes et al., 2006), and there have been previous studies emphasizing its importance against T. gondii infection in maternal-fetal interface (Ferro et al., 2008; Flores et al., 2008; de Oliveira Gomes et al., 2011; Barbosa et al., 2014). This evidence concerns the gene MIF and infection.