In the context of M4 and M5 AML, NF-κB directly upregulates the transcription of eIF4E; this association has not been seen in other AML subtypes or normal hematopoietic cells (177) suggesting that other transcription factors besides c-Myc may upregulate eIF4E in a context-dependent or tissue-specific manner. This evidence concerns the gene NFKB1 and acute myeloid leukemia.