Indeed, the activity of eEF2K is inhibited by multiple oncogenic signals; however, high levels of eEF2K have been shown to increase the adaptability of tumor cells in nutrient deprivation accounting for the observation that elevated eEF2K transcript levels are associated with poor prognosis in medulloblastoma and glioblastoma multiforme (56) (Table 1; Table S1 in Supplementary Material). This evidence concerns the gene EEF2K and medulloblastoma.