Examples of these genes include c-Jun, calcineurin B, CDK12, and BTG1. Interestingly, eIF3 has opposing translational regulatory functions: it promotes the translation of c-JUN, which is a proto-oncogene; while it blocks the translation of BTG1, whose overexpression impairs invasive growth in human lung cancer cells (72). The gene discussed is BTG1; the disease is lung carcinoma.