CPEB4 associates with a large number of CPE-containing mRNAs, which seem to be tissue-specific (134, 135), and steers the translational landscape to support the phenotypic hallmarks of malignancy, i.e., invasive growth (pancreatic adenocarcinoma), uncontrolled tumor growth, and aberrant angiogenesis (high-grade gliomas) (134). Here, CPEB4 is linked to glioma.