Interferon-γ is a potent PD-L1 inducer in tumor cell populations.21 B16 and ID8agg TICs expressed interferon-γ-inducible PD-L1, which expression was blunted in PD-L1lo TIC as expected (Figures 4a and b), and also confirming the stringent PD-L1 knockdown effect in clones. The gene discussed is CD274; the disease is neoplasm.