These three molecules all exert tumor cell-intrinsic effects, including regulating tumor mTOR, its regulators or its targets.3,10,32 As mTOR could have a critical role in TIC generation,33 the concept that tumor cell-intrinsic immunoglobulin superfamily members exert related, important signaling effects in cancer immunopathogenesis or treatment responses merits much additional attention. This evidence concerns the gene MTOR and cancer.