RPTOR and neoplasm: We recently showed that in total B16 and ID8agg cell cultures, tumor PD-L1 promoted tumor cell proliferation and mTORC1 activation.3 We show here that PD-L1 increased the mTORC1 component rptor in B16 and ID8agg TIC, and also in human ES2 TIC, consistent with increased mTORC1 signals.