In particular, the authors demonstrated that the IRF2 mutational status is associated with both colon and rectal cancer, whereas mutations in other genes involved in IFN signaling pathway were uniquely associated with colon (IFN-γ and IRF3) or rectal cancer (IFNGR1, IFNGR2, IRF4, IRF6, and IRF8). The gene discussed is IFNGR1; the disease is rectal cancer.