CD8A and cancer: The immunoregulatory effect of IFNs includes the up-regulation of tumor antigens expression (33), the DCs tumor antigen presentation to T cells, the acquisition of CD8+ T cell effector phenotype (34, 35), the down-regulation of (Treg) (36, 37), the inhibition of myeloid-derived suppressor cells (MDSCs) accumulation (38) (Treg and MDSCs accumulate in circulation of cancer patients where they negatively regulate the cytotoxic activity of T cells), and the monocyte differentiation in M1-polarized immunostimulatory macrophages (39).