Furthermore, after incubation with mAb against TLR11, phosphorylation of ERK1/2 1 h post-infection were dramatically inhibited (p < 0.01, Figure 5D) and extracellular secretion of IL-12p40 was reduced by 72.5% at 24 h and 64.2% at 48 h (p < 0.01, Figure 5E), while incubation with control serum could not cause inhibition (p > 0.05). This evidence concerns the gene MAPK3 and infection.