ALS has been associated with alterations of energy homeostasis induced by mitochondrial muscle breakdown (10), and by trophic factors such as insulin-like growth factor-1 (IGF-1) and glial cell-derived neurotrophic factor that are secreted by skeletal muscle, and are known to stabilize the NMJ and thereby promote motoneuron survival (11, 12). This evidence concerns the gene IGF1 and amyotrophic lateral sclerosis.