Che et al confirmed that β1, 4-N-acetylgalactosaminyltransferase III (B4GALNT3) regulated GalNAcβ1-4GlcNAc (LacdiNAc) on the epidermal growth factor receptor (EGFR) to promote the stemness and invasiveness of colorectal cancer cells (Che et al., 2014). Here, B4GALNT3 is linked to colorectal cancer.