RBFOX3 and Alzheimer disease: Thus, taking into the consideration the role of NeuroD1 in controlling cell fate and differentiation in hippocampal neurogenesis, one may assume that EE-induced reduction of NeuroD1 expression in Aβ-treated or aged rats could relate to some kind of preservation of neurogenic cells in the non-differentiated state, particularly, in the group of aging rats where elevation of NeuN+ neurons number was less evident than in the group with AD model.