Our research results were consistent with the others, for example, the NLRP6 inflammasome has been shown to promote recovery after peripheral nerve injury by dampening inflammatory responses independently of IL-1β and inflammasomes (Ydens et al., 2015); the NLRP6 inflammasome was shown to inhibit colitis and colorectal tumorigenesis (Chen et al., 2011; Elinav et al., 2011; Normand et al., 2011), and dampen inflammatory signaling by negatively regulating canonical NF-κB activation pathway (Anand et al., 2012). Here, IL1B is linked to colitis.