Soon afterwards, we verified progesterone soft capsule (brand name: Utrogestan), as a kind of natural micronized progesterone which was capable of detecting in serum after being taken orally or vaginally was an effective oral alternative for inhibiting premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients13–16. Here, PLOD1 is linked to polycystic ovary syndrome.