VIPR2 and schizophrenia: The 22q11.2 deletion was the first CNVs reported as implicated in schizophrenia, and the prevalence of 22q11.2 deletion in patients with SZ is about 0.3%.23, 24 However, Rees et al. further showed that duplications of 22q11.2 may protect against schizophrenia.25 Moreover, micro-deletions at 1q21.1,24, 26 2p16.3,27, 28 3q29,27, 29 15q11.2,26, 28 15q13.3,24, 26, 27 17p12,28 17q12,30 and duplications on 1p36.33,25 15q13.1,28 16p11.2,25, 29, 31 16p13.1,28, 32 VIPR2,27, 33 and CGNL125 have been identified to be associated with an increased risk of schizophrenia.34