PTPRD and diabetes mellitus: Liou et al. suggested that rs28362691 in nuclear factor kappa B subunit 1 (NFKB1) might be involved in the development of treatment refractory schizophrenia in Han Chinese individuals.68 Yu et al. reported that protein tyrosine phosphatase, receptor type D (PTPRD) and glutamine-fructose-6-phosphate transaminase 2 (GFPT2) polymorphisms were associated with the weight gain effects of atypical antipsychotic medications.69 Both PTPRD and GFPT2 have been reported as susceptible genes of diabetes, suggesting a novel mechanism for weight gain induced through antipsychotic therapy.