Our study showed that ZW1 upregulated aromatase expression by activation of CREB phosphorylation; this was consistent with previous reports that PDE5 inhibitors could stimulate CREB phosphorylation in B16 melanoma cells in vitro and an Alzheimer’s disease mouse model in vivo41, 52. This evidence concerns the gene CREB1 and early-onset autosomal dominant Alzheimer disease.